The equine intestinal mucosa is intimately involved in maintaining homeostasis both on a systemic level by controlling extracellular fluid movement and at the local level to maintain barrier function. Horses are particularly susceptible to the clinical syndrome of colic, with the most severe cases involving strangulating obstruction that induces ischemia. Because of the mucosal vascular architecture, the mucosal epithelium is particularly susceptible to ischemic injury. The potential for reperfusion injury has been investigated and found to play a minimal role. However, inflammation does affect mucosal repair. Mechanisms of repair, including villus contraction, epithelial restitution, and tight junction closure, are critical to reforming the mucosal barrier. Nonsteroidal anti-inflammatory drugs have an impact on this repair, particularly at the level of the tight junctions. Completion of mucosal regeneration requires proliferation, which is now being actively studied in equine enteroids. All of these aspects of equine mucosal pathobiology are reviewed in depth.

中文翻译：

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马肠道粘膜病理生物学。

马肠粘膜通过控制细胞外液的运动而在系统水平上和局部水平上均密切参与维持体内稳态，以维持屏障功能。马特别容易患绞痛的临床症状，最严重的情况涉及绞窄性梗阻，引起缺血。由于粘膜血管结构，粘膜上皮特别容易受到缺血性损伤。已经对潜在的再灌注损伤进行了研究，发现其作用很小。但是，炎症确实会影响粘膜修复。修复机制，包括绒毛收缩，上皮恢复和紧密连接闭合，对于改革粘膜屏障至关重要。非甾体类抗炎药会对修复产生影响，特别是在紧密连接处。粘膜再生的完成需要增生，目前正在马类肠道中积极研究增生。马粘膜病理生物学的所有这些方面都得到了深入的审查。