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Detection of Emerging Zoonotic Pathogens: An Integrated One Health Approach.
Annual Review of Animal Biosciences ( IF 8.7 ) Pub Date : 2017-11-17 , DOI: 10.1146/annurev-animal-030117-014628
Brian H Bird 1 , Jonna A K Mazet 1
Affiliation  

The emergence of novel zoonotic pathogens is one of the greatest challenges to global health security. The advent of increasingly sophisticated diagnostics tools has revolutionized our capacity to detect and respond to these health threats more rapidly than ever before. Yet, no matter how sophisticated these tools become, the initial identification of emerging infectious diseases begins at the local community level. It is here that the initial human or animal case resides, and it is here that early pathogen detection would have maximum benefit. Unfortunately, many areas at highest risk of zoonotic disease emergence lack sufficient infrastructure capacity to support robust laboratory diagnostic systems. Multiple factors are essential for pathogen detection networks, including an understanding of the complex sociological and ecological factors influencing disease transmission risk, community engagement, surveillance along high-risk human-animal interfaces, and a skilled laboratory workforce. Here we discuss factors relevant to the emerging disease paradigm, recent technical advances in diagnostic methods, and strategies for comprehensive and sustainable approaches to rapid zoonotic disease detection.

中文翻译:

新兴的人畜共患病病原体的检测:一种综合的健康方法。

新型人畜共患病原体的出现是全球卫生安全面临的最大挑战之一。日益复杂的诊断工具的出现彻底改变了我们检测和应对这些健康威胁的能力,比以往任何时候都快。但是,无论这些工具变得多么复杂,对新出现的传染病的最初识别都始于当地社区。最初的人类或动物病例就在这里,早期的病原体检测将在这里发挥最大的作用。不幸的是,许多人畜共患疾病风险最高的地区缺乏足够的基础设施来支持强大的实验室诊断系统。多种因素对于病原体检测网络至关重要,包括对影响疾病传播风险的复杂社会和生态因素的理解,社区参与,对高风险人畜界面的监视以及熟练的实验室人员。在这里,我们讨论与新兴疾病范例有关的因素,诊断方法的最新技术进步以及快速,有效的人畜共患病检测的综合和可持续方法的策略。
更新日期:2019-11-01
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