Corticosteroids are a class of hormones released by the adrenal cortex, which includes glucocorticoids and mineralocorticoids. Glucocorticoids have an important role in the metabolism of carbohydrates, proteins and calcium and effective anti-inflammatory and immunosuppressive activity. Due to their intense immunomodulatory and anti-inflammatory activity, glucocorticoids are used in the treatment of various inflammatory, malignant, allergic conditions such as rhinitis, asthma, dermatological, rheumatic, ophthalmic and neurological diseases, as well as after organ transplants. They are the most widely prescribed drugs in the world. The objective of this review is to provide an overview of the analytical methods in pharmaceutical matrices for determination of corticosteroids. In this study, the predominance of liquid chromatography methods for the analysis of corticosteroids from pharmaceutical products is evident for both liquid and semisolid dosage forms as well as for solids. The same can be said for topical, oral and parenteral formulations. Methods such as spectrophotometry are also used, but given the advantages of chromatographic methods such as better selectivity and sensitivity, they have become the choice for analysis of these drugs, however, most methods still do not meet the credentials of "green chemistry."

中文翻译：

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对测定糖皮质激素的药物基质中分析方法的批判性评论。

皮质类固醇是肾上腺皮质释放的一类激素，包括糖皮质激素和盐皮质激素。糖皮质激素在碳水化合物，蛋白质和钙的代谢以及有效的抗炎和免疫抑制活性中具有重要作用。由于其强烈的免疫调节和抗炎活性，糖皮质激素可用于治疗各种炎性，恶性，过敏性疾病，例如鼻炎，哮喘，皮肤病，风湿病，眼科和神经病，以及器官移植后。它们是世界上使用最广泛的药物。这篇综述的目的是概述用于测定皮质类固醇的药物基质中的分析方法。在这个研究中，对于液体和半固体剂型以及固体，液相色谱法在分析医药产品中的皮质类固醇方面的优势是显而易见的。对于局部，口服和肠胃外制剂也可以这样说。还使用了分光光度法等方法，但是鉴于色谱法的优势（例如更好的选择性和灵敏度），它们已成为分析这些药物的选择，但是，大多数方法仍不符合“绿色化学”的要求。