In the present study, authors want to encourage the research exertions through structureactivity relationship for the identification of effective molecules for the treatment of Human immunodeficiency virus because nowadays AIDS is considered as one of the main causes of death in human beings. A diversity of biological resources has been searched and developed for the treatment of HIV but unfortunately, until now, no medicine is found to be fully effective and safe for the cure of patients. Human immunodeficiency virus is a type of lentivirus which causes the infection of HIV and once it enters the human body, it stays for a longer period of time triggering immunodeficiency syndrome. For searching and developing new potent and effective anti-HIV molecules, medicinal chemists have engaged in countless targets with the structure-activity relationship (SAR) of molecules and on this basis, many antiretroviral therapies have been developed to cure HIV infection. Most of these new searched molecules have been found to be clinically active against various types of AIDS patient and auxiliary research in this area may lead to better treatment in the near future. This article encompasses and highlights the recent advancement of innumerable inhibitors laterally through synthetic, semi-synthetic and structure-activity relationship approaches.

在本研究中，作者希望通过结构活性关系来鼓励人们进行研究，以鉴定用于治疗人类免疫缺陷病毒的有效分子，因为当今艾滋病已被认为是人类死亡的主要原因之一。已经寻找和开发了用于治疗HIV的多种生物资源，但不幸的是，直到现在，还没有发现任何药物可以完全有效和安全地治愈患者。人类免疫缺陷病毒是一种慢病毒，会引起HIV感染，一旦进入人体，它会停留更长时间，从而引发免疫缺陷综合症。为了寻找和开发新的有效有效的抗HIV分子，药物化学家通过分子的构效关系（SAR）参与了无数目标，并在此基础上开发了许多抗逆转录病毒疗法来治愈HIV感染。已经发现这些新搜索的分子中的大多数对多种类型的AIDS患者具有临床活性，在这一领域的辅助研究可能会在不久的将来带来更好的治疗。本文涵盖并突出了通过合成，半合成和结构-活性关系方法在横向上无数抑制剂的最新进展。已经发现这些新搜索的分子中的大多数对多种类型的AIDS患者具有临床活性，在这一领域的辅助研究可能会在不久的将来带来更好的治疗。本文涵盖并突出了通过合成，半合成和结构-活性关系方法在横向上无数抑制剂的最新进展。已经发现这些新搜索的分子中的大多数对多种类型的AIDS患者具有临床活性，在这一领域的辅助研究可能会在不久的将来带来更好的治疗。本文涵盖并突出了通过合成，半合成和结构-活性关系方法在横向上无数抑制剂的最新进展。