The development of successful scaffolds for bone tissue engineering requires concurrent engineering that combines different research fields. In previous studies, phenomenological computational models predicted the mechanical properties of a scaffold in a simple loading condition using the mechano-regulation theory. Therefore, the aim of this study is to predict the mechanical properties of an optimum scaffold required for cartilage regeneration using three-dimensional knee joint developed from medical imaging and mechano-regulation theory. It was predicted that the scaffold with optimal mechanical properties would result in greater amounts of cartilage tissue formation than without a scaffold. The results demonstrated the ability of the algorithms to design optimized scaffolds with target properties and confirmed the applicability of set techniques for bone tissue engineering. The scaffolds were optimized to suit the site-specific loading requirements, and the results reveal a new approach for computational simulations in tissue engineering.

中文翻译：

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使用有限元分析的软骨再生支架的最佳机械性能。

成功的骨组织工程支架开发需要同时进行的工程结合了不同的研究领域。在以前的研究中，现象学计算模型使用机械调节理论预测了简单负载条件下脚手架的机械性能。因此，本研究的目的是使用医学影像学和机械调节理论开发的三维膝关节，预测软骨再生所需的最佳支架的力学性能。据预测，具有最佳机械性能的支架将比没有支架的支架导致更多的软骨组织形成。结果证明了该算法设计具有目标特性的优化支架的能力，并证实了骨技术用于骨组织工程的适用性。支架进行了优化，以适应特定位置的负载要求，结果揭示了一种用于组织工程计算仿真的新方法。