Flavonoids are polyphenolic compounds that not only impart coloration to plants and fruits, but also protect plants from pathogens, radiation, etc. They serve as a nutrient to plants and possess immense anti-oxidant properties. Research has shown that they exhibit anti-inflammatory, anti-cancer, and neuroprotective properties in both in vitro and in vivo analyses. Luteolin is one such flavonoid belongs to the group of flavones present in herbs such as thyme, chamomile, celery, and green pepper. The epidemiological data on luteolin consumption show that luteolin has anti-inflammatory activity and protects from diseases associated with inflammation. The present study assessed the anti-nociceptive properties of luteolin, a potent anti-inflammatory agent, in mice. The results demonstrated that luteolin produces a significant and dose-dependent increase in hot plate latency and tail withdrawal time. It also reduced the number of abdominal constrictions and paw licking induced by acetic acid and glutamate, respectively. Luteolin inhibited the nociceptive responses in both phases of formalin test. The anti-inflammatory property of luteolin was also confirmed with different anti-inflammatory mice models induced by carrageenan and air pouch. Behavioral changes in luteolin-treated mice were assessed with open-field test to confirm the muscle relaxant property. The results of the current study from various pain and inflammatory models confirms that luteolin possess potent anti-nociceptive and anti-inflammatory properties and can thus be used as a drug in pain management.

中文翻译：

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木犀草素对小鼠的抗伤害感受和消炎作用的评估。

黄酮类化合物是多酚类化合物，不仅可以赋予植物和水果以色泽，还可以保护植物免受病原体，放射线等的侵害。它们是植物的营养物质，具有巨大的抗氧化特性。研究表明，它们在体外和体内分析中均具有抗炎，抗癌和神经保护特性。木犀草素是一种这样的类黄酮，属于百里香，洋甘菊，芹菜和青椒等草药中的黄酮类。有关食用木犀草素的流行病学数据表明，木犀草素具有抗炎活性，可预防与炎症有关的疾病。本研究评估了木犀草素（一种有效的消炎药）在小鼠中的抗伤害感受特性。结果表明，木犀草素在热板潜伏期和尾巴撤回时间上产生了明显的剂量依赖性增加。它还分别减少了乙酸和谷氨酸引起的腹部收缩和舔爪的次数。木犀草素在福尔马林测试的两个阶段均抑制伤害感受性反应。木犀草素和气囊诱导的不同抗炎小鼠模型也证实了木犀草素的抗炎特性。通过野外试验评估木犀草素处理的小鼠的行为变化，以确认肌肉松弛特性。来自各种疼痛和炎症模型的当前研究结果证实，木犀草素具有有效的抗伤害感受和抗炎特性，因此可以用作治疗疼痛的药物。