Diallyl disulfide (DADS) is an organosulfur compound derived mainly from garlic and genus Allium plants, which possess diverse biological properties. The aim of the present study was to evaluate the antiarthritic activity of DADS in rats with arthritis induced using complete Freund's adjuvant (CFA). DADS (20 mg/kg and 50 mg/kg) was administered and tested against CFA-induced arthritic rats by assessing various parameters: body weight, paw volume, arthritic score, organ indices (spleen and thymus), hematological and biochemical parameters, and proinflammatory cytokines. Histopathological analyses were also performed. The treatment of rats with DADS provoked significant reductions in paw volume, edema formation, arthritic score, and organ indices, together with significant improvement in body weight. DADS treatment also improved joint destruction and reduced inflammation, which was supported by histopathological studies. DADS significantly reduced the white blood cell count and improved red blood cell count in CFA-induced rats. The anti-arthritic activity in the CFA-induced rats was further confirmed by biochemical analysis. These findings suggest that DADS prevented cartilage destruction, improved health status, and reduced inflammation by decreasing the expression of proinflammatory cytokines in arthritis-induced rats. Hence, DADS may be a potential therapeutic candidate for the treatment of rheumatoid arthritis.

中文翻译：

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二烯丙基二硫对弗氏佐剂诱发的关节炎大鼠模型的抗关节炎活性。

二烯丙基二硫化物（DADS）是一种主要来自大蒜和葱属植物的有机硫化合物，具有多种生物学特性。本研究的目的是评估DADS在使用完全弗氏佐剂（CFA）诱发的关节炎大鼠中的抗关节炎活性。给药DADS（20 mg / kg和50 mg / kg），并通过评估各种参数对CFA诱发的关节炎大鼠进行测试：体重，爪子体积，关节炎评分，器官指数（脾脏和胸腺），血液学和生化指标以及促炎细胞因子。还进行了组织病理学分析。用DADS进行的大鼠治疗可显着减少爪子体积，水肿形成，关节炎评分和器官指数，并显着减轻体重。DADS治疗还改善了关节破坏并减少了炎症，这得到了组织病理学研究的支持。DADS在CFA诱导的大鼠中显着减少了白细胞计数，并改善了红细胞计数。生化分析进一步证实了CFA诱导的大鼠的抗关节炎活性。这些发现表明，DADS通过降低关节炎诱发的大鼠中促炎细胞因子的表达来预防软骨破坏，改善健康状况并减少炎症。因此，DADS可能是类风湿关节炎的潜在治疗候选药物。生化分析进一步证实了CFA诱导的大鼠的抗关节炎活性。这些发现表明，DADS通过降低关节炎诱发的大鼠中促炎细胞因子的表达来预防软骨破坏，改善健康状况并减少炎症。因此，DADS可能是类风湿关节炎的潜在治疗候选药物。生化分析进一步证实了CFA诱导的大鼠的抗关节炎活性。这些发现表明，DADS通过降低关节炎诱发的大鼠中促炎细胞因子的表达来预防软骨破坏，改善健康状况并减少炎症。因此，DADS可能是类风湿关节炎的潜在治疗候选药物。