Glycosylation is an important posttranslational modification in mammals. The glycans of glycoproteins are classified into two groups, namely, N-glycans and O-glycans, according to their glycan-peptide linkage regions. Recently, O-mannosyl glycan, an O-glycan, has been shown to be important in muscle and brain development. A clear relationship between O-mannosyl glycans and the pathomechanisms of some congenital muscular dystrophies has been established in humans. Ribitol-5-phosphate is a newly identified glycan component in mammals, and its biosynthetic pathway has been elucidated. The discovery of new glycan structures and the identification of highly regulated mechanisms of glycan processing will help researchers to understand glycan functions and develop therapeutic strategies.

中文翻译：

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哺乳动物O-甘露糖基聚糖：生物化学和糖病理学。

糖基化是哺乳动物中重要的翻译后修饰。糖蛋白的聚糖根据其聚糖-肽键合区域分为N-聚糖和O-聚糖两类。最近，已证明O-甘露糖基聚糖（O-聚糖​​）在肌肉和大脑发育中很重要。在人类中，O-甘露糖基聚糖与某些先天性肌营养不良的致病机理之间存在明确的关系。磷酸利必泰5是哺乳动物中新发现的聚糖成分，其生物合成途径已经阐明。新糖结构的发现和糖加工过程的高度调控机制的确定将有助于研究人员了解糖功能并制定治疗策略。