Oral drug delivery systems provide the most convenient, noninvasive, readily acceptable alternatives to parenteral systems. In the current work, eggshell-derived calcium carbonate (CaCO₃) nanoparticles were used to develop enteric drug delivery system in the form of tablets. CaCO₃ nanoparticles were manufactured using top-down ball-milling method and characterized by X-ray diffractometry (XRD) and transmission electron microscopy (TEM) and loaded with 5-fluorouracil as a model drug. Tablets with varying CaCO₃ core and binder compositions were fabricated and coated with Eudragit S100 or Eudragit L100. Suitability for enteric delivery of the tablets was tested by oral administration to rabbits and radiography. Radiograph images showed that the tablet remained in the stomach of the rabbit for up to 3 hours. Further modifications of these biomaterial-derived nanoparticles and the coatings will enable manufacturing of stable formulations for slow or controlled release of pharmaceuticals for enteric delivery.

中文翻译：

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生物材料衍生的碳酸钙纳米颗粒用于肠溶药物递送。

口服药物递送系统提供了肠胃外系统最方便，无创，易于接受的替代方法。在当前的工作中，蛋壳衍生的碳酸钙（CaCO ₃）纳米颗粒被用于开发片剂形式的肠溶药物递送系统。使用自上而下的球磨法制造CaCO ₃纳米颗粒，并通过X射线衍射（XRD）和透射电子显微镜（TEM）进行表征，并负载5-氟尿嘧啶作为模型药物。碳酸钙含量不同的片剂₃制备芯和粘合剂组合物并用Eudragit S100或Eudragit L100包衣。通过对兔子口服给药和放射照相法测试了片剂的肠内递送的适用性。射线照片显示该片剂在兔子的胃中保留了长达3个小时。这些生物材料衍生的纳米颗粒和包衣的进一步修饰将使得能够制造稳定的制剂，以缓慢或受控地释放用于肠递送的药物。