Fourteen essential oils (EOs) from selected live germplasm of medicinal plants have been tested for their antitrypanosomal and cytotoxic activity. These plants have been domesticated and maintained under experimental cultivation. Their EOs were tested on epimastigote forms of Trypanosoma cruzi strain Y and human lung fibroblasts LC5 cell line, along with the major components of the active oils, both separately and in binary combinations. Mentha rotundifolia, Thymus zygis, T. vulgaris and Hyssopus officinalis were the most active EOs against T. cruzi. Among the main components of these EOs (1-8-cineole, thymol, p-cymene, piperitenone oxide, β-pinene, γ-terpinene, carvacrol and linalool), the most active against the parasite and less toxic to human cells was thymol. In general, the activity of the main components did not exceed that of their origin EO, and the study of the activity of these compounds in combination indicates the existence of antagonistic and synergistic effects depending on the concentration tested.

中文翻译：

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精选药用植物精油的锥虫杀菌作用。主要组成部分之间的协同作用。

已对选自药用植物活体种质的十四种精油（EOs）的抗锥虫和细胞毒性活性进行了测试。这些植物已经驯化并保持在实验栽培下。他们的EOs在克氏锥虫Y菌株和人肺成纤维细胞LC5细胞系的假鞭毛体形式上以及活性油的主要成分中进行了单独和二元组合测试。薄荷脑（Mentha rotundifolia），百里香（Thymus zygis），寻常型T.Vulgaris和厚皮草（Hyssopus officinalis）是最有效的针对拟南芥（T. cruzi）的EOs。在这些EO的主要成分（1-8-桉树脑，百里香酚，对-异丙苯，氧化哌啶酮，β-pine烯，γ-萜品烯，香芹酚和芳樟醇）中，对寄生虫活性最高且对人体细胞毒性较小的是麝香草酚。一般来说，