Topical administration of drugs presents some advantages over other routes; the drug can be administered in the anatomical region to be treated, limiting the systemic distribution and side effects. However, the structure of the skin makes it a highly effective barrier to drug permeation. Amongst the strategies to overcome this obstacle, liposomes are interesting vehicles for delivering the drugs into the skin, the synovial cavity or other regions affected by inflammatory or degenerative conditions. Liposomes are lipid carriers of nanometric size formed by phospholipid bilayers. They have the advantages of preparation feasibility and biological compatibility associated with the possibility of carrying either lipophylic and/or hydrophylic compounds, and have been extensively used in various drug delivery systems, for drug targeting, controlled release and permeation enhancement of drugs. Conventional liposomes are not very stable and not suitable for dermal administration after topical application, since they accumulate on the skin surface due to the rigidity of the lipid layers and suffer dehydration, culminating in their fragmentation. Other formulations have emerged in the meantime, such as transfersomes, niosomes or ethosomes. The present work consists of a review on the published scientific papers regarding the development of liposomal formulations containing non-steroidal anti-inflammatory drugs for the purpose of relieving the symptomatology of inflammatory and degenerative ailments. The exposition summarizes data relating to liposome type, composition, preparation method, liposome characterization, topical vehicle used, in vitro permeation studies performed, in vivo anti-inflammatory assays carried out and results obtained in the different studies published in the last five years.

局部给药与其他途径相比具有一些优势。该药物可以在要治疗的解剖区域中给药，限制了全身分布和副作用。但是，皮肤的结构使其成为有效的药物渗透屏障。在克服这一障碍的策略中，脂质体是用于将药物递送至皮肤，滑膜腔或受炎症或退行性疾病影响的其他区域的有趣载体。脂质体是由磷脂双层形成的纳米级脂质载体。它们具有制备可行性和生物相容性的优势，并带有携带脂族和/或亲水性化合物的可能性，并且已广泛用于各种药物递送系统中，用于靶向药物，药物的控释和渗透增强。常规脂质体不是非常稳定并且不适用于局部施用后的皮肤施用，因为它们由于脂质层的刚性而积聚在皮肤表面上并且遭受脱水，最终导致其破碎。同时出现了其他制剂，例如传递体，脂质体或质体。目前的工作包括对已发表的有关减轻非炎症性和退行性疾病症状的非甾体类抗炎药的脂质体制剂研发的科学论文的综述。博览会总结了有关脂质体类型，组成，制备方法，脂质体表征，所用局部用载体，进行的体外渗透研究的数据，