The accessibility to next-generation sequencing (NGS) techniques has enabled the sequencing of hundreds of genomes of species representing all kingdoms. In the case of fungi, genomes of more than a thousand of species are publicly available. This is far from covering the number of 2.2–3.8 million fungal species estimated to populate the world but has significantly improved the resolution of the fungal tree of life. Furthermore, it has boosted systematic evolutionary analyses, the development of faster and more accurate diagnostic analyses of pathogenic strains or the improvement of several biotechnological processes. Nevertheless, the diversification of the nature of fungal species used as model has also weakened research in other species that were traditionally used as reference in the pre-genomic era. In this context, and after more than 65 years since the first works published by Pontecorvo, Aspergillus nidulans remains as one of the most referential model filamentous fungus in research fields such as hyphal morphogenesis, intracellular transport, developmental programs, secondary metabolism, or stress response. This mini-review summarizes how A. nidulans has contributed to the progress in these fields during the last years, and discusses how it could contribute in the future, assisted by NGS and new-generation molecular, microscopy, or cellular tools.

中文翻译：

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后基因组时代的构巢曲霉：一种用于信号传导和体内稳态机制研究的顶级丝状真菌。

下一代测序（NGS）技术的可访问性使得能够对代表所有王国的数百种物种的基因组进行测序。就真菌而言，可公开获得一千多个物种的基因组。这远未涵盖估计在世界上居住的2.2–380万种真菌物种的数量，但已大大提高了真菌生命树的分辨率。此外，它促进了系统的进化分析，对病原菌株的更快，更准确的诊断分析的发展或几种生物技术过程的改进。然而，作为模型的真菌物种的自然多样性也削弱了其他在传统上用作前基因组时代参考的物种的研究。在这种情况下，构巢曲霉仍然是研究领域中最有参考价值的丝状真菌之一，例如菌丝形态发生，细胞内运输，发育程序，次级代谢或应激反应。这份小型综述概述了构巢曲霉在过去几年中如何为这些领域的发展做出贡献，并讨论了在NGS和新一代分子，显微镜或细胞工具的帮助下，构巢曲霉将来如何做出贡献。