ATP-binding cassette (ABC) transporters constitute one of the biggest and most conserved protein families in the evolutionary scale. Many of them are of enormous clinical relevance, due to their relationship with genetic diseases and drug resistance during the treatment of cancer and infectious diseases. Leishmaniasis is a major and globally widespread group of parasitic diseases, whose treatment has been complicated by the expansion of resistance to conventional drugs. Here, we review the current knowledge about ABC transporters in Leishmania spp, with special attention to their relationship with the drug-resistance phenotype.

中文翻译：

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原生动物寄生虫利什曼原虫中的ABC转运蛋白。

ATP结合盒（ABC）转运蛋白是进化规模上最大和最保守的蛋白质家族之一。由于它们与遗传疾病的关系以及在癌症和传染病治疗期间的耐药性，它们中的许多具有重大的临床意义。利什曼病是一种主要且全球性的寄生虫病，由于对常规药物的耐药性扩大，其治疗变得复杂。在这里，我们回顾了有关利什曼原虫中ABC转运蛋白的当前知识，并特别注意了它们与耐药性表型的关系。