Here we present an autopsy case of chronic traumatic encephalopathy (CTE) in a 36-year-old man. He had a history of febrile seizures at the age of four and was severely demented at age 10 when he was admitted to a mental hospital. He had suffered repetitive self-harm, such as frequent banging of the head on the wall in his hospital record, but he had no clear history between the ages of four and ten. Autopsy revealed global cerebral atrophy, including the basal ganglia, thalamus, hippocampus, amygdala, mammilary bodies and lateral geniculate bodies. This case showed typical pathological features of CTE. Phosphorylated tau (p-tau)-positive neurofibrillary tangles (NFTs) and neuropil threads (NT) we are widely distributed in the brain, especially in the depth of the cerebral sulci. NFT and NT were also found in the basal ganglia, thalamus, amygdala and brainstem. Scanty β-amyloid deposits were found in the motor and sensory cortices, but α-synuclein was completely negative in the brain. This example showed that CTE can occur in young ages and that even children can experience CTE dementia.

中文翻译：

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验尸证明儿童发作的慢性创伤性脑病。

在这里，我们介绍了一名36岁的慢性创伤性脑病（CTE）的尸检病例。他有四岁时出现高热惊厥的病史，并在他入精神病院时在10岁时严重痴呆。他遭受了反复性的自我伤害，例如在他的医院记录中经常用头撞墙，但他在四到十岁之间没有明确的病史。尸检显示全脑萎缩，包括基底神经节，丘脑，海马，杏仁核，乳突和外侧膝状体。该病例显示了CTE的典型病理特征。磷酸化的tau（p-tau）阳性神经原纤维缠结（NFT）和Neuropil线（NT）我们广泛分布在大脑中，尤其是在脑沟深处。NFT和NT也发现于基底神经节，丘脑，杏仁核和脑干。在运动皮层和感觉皮层中发现很少的β-淀粉样蛋白沉积物，但大脑中的α-突触核蛋白完全阴性。这个例子表明，CTE可能发生在年轻年龄段，甚至儿童也可能患有CTE痴呆。