Infections with cytomegalovirus (CMV) can induce severe complications after solid organ transplantation (SOT). The prognosis for ganciclovir-resistant CMV infection and disease is particularly poor. Whereas adoptive transfer of CMV-specific T cells has emerged as a powerful tool in hematopoietic stem cell transplant patients, its translation into the SOT setting remains a significant challenge as underlying immunosuppression inhibits the virus-specific T-cell response in vivo. Here, we demonstrate successful expansion and adoptive transfer of autologous CMV-specific T cells from a seronegative recipient of a seropositive lung allograft with ganciclovir-resistant CMV disease, resulting in the long-term reconstitution of protective anti-viral immunity, CMV infection, disease-free survival and no allograft rejection.

中文翻译：

---

肺移植后更昔洛韦耐药性CMV疾病的过继T细胞免疫疗法。

巨细胞病毒（CMV）感染可在实体器官移植（SOT）后引起严重的并发症。更昔洛韦耐药性巨细胞病毒感染和疾病的预后特别差。尽管CMV特异性T细胞的过继转移已成为造血干细胞移植患者的有力工具，但由于潜在的免疫抑制作用在体内抑制了病毒特异性T细胞应答，其向SOT设置的转化仍然是一项重大挑战。在这里，我们证明了从更昔洛韦耐药性CMV血清阳性肺同种异体移植的血清反应阴性受体成功扩增和过继转移自体CMV特异性T细胞，导致长期重建了保护性抗病毒免疫，CMV感染，疾病生存，无异体移植排斥。