OBJECTIVES Meta-analyses have now confirmed that persistent infections with cytomegalovirus (CMV) can accelerate the onset of diseases of ageing, notably cardiovascular pathologies. We address the circumstances in which the association may be strong enough to warrant intervention to reduce the viral burden. RESULTS We compare markers of the burden of CMV with established indices of vascular pathology in healthy adults (n = 82) and in renal transplant recipients (RTR; n = 81). Levels of all inflammatory and vascular biomarkers and CMV antibodies were higher in RTR, and flow-mediated dilation (FMD) values were lower indicating inferior endothelial function. In multivariable regression models without adjustment for estimated glomerular filtration rate (eGFR), CMV antibody levels, age and gender were independently associated with FMD in RTR, whilst only CRP associated with FMD in healthy adults. After adjustment for eGFR, associations between CMV antibody and FMD in RTR were reduced. METHODS Carotid intima-media thickness, FMD, eGFR and plasma levels of CMV antibodies (reactive with a lysate, CMV IE-1 or CMV gB), ICAM-1, VCAM-1, P-selectin, sIFNαR2, sTNFR1, sCD14 and CRP were determined. CONCLUSION Levels of CMV antibody predict declining endothelial health in RTR and not in healthy adults, presumably by reflecting a high burden of CMV. The levels of CMV antibodies were a poor reflection of plasma biomarkers thought to reflect 'inflammaging' or vascular damage.

中文翻译：

---

与普通人群相比，巨细胞病毒的高负担更清楚地表明移植受者的血管健康状况不佳。

目标 荟萃分析现已证实，持续感染巨细胞病毒 (CMV) 可加速衰老疾病的发作，尤其是心血管疾病。我们解决了这种关联可能足够强大以保证干预以减少病毒负担的情况。结果 我们将 CMV 负担的标志物与健康成人 (n = 82) 和肾移植受者 (RTR; n = 81) 的既定血管病理学指标进行比较。RTR 中所有炎症和血管生物标志物和 CMV 抗体的水平较高，而流动介导的扩张 (FMD) 值较低，表明内皮功能较差。在未调整估计肾小球滤过率 (eGFR) 的多变量回归模型中，CMV 抗体水平、年龄和性别与 RTR 中的 FMD 独立相关，而只有 CRP 与健康成人的 FMD 相关。在调整 eGFR 后，RTR 中 CMV 抗体和 FMD 之间的关联降低了。方法 颈动脉内膜中层厚度、FMD、eGFR 和 CMV 抗体（与裂解物、CMV IE-1 或 CMV gB 反应）、ICAM-1、VCAM-1、P-选择素、sIFNαR2、sTNFR1、sCD14 和 CRP 的血浆水平被确定。结论 CMV 抗体水平预测 RTR 而不是健康成人的内皮健康下降，这可能反映了 CMV 的高负担。CMV 抗体水平不能很好地反映被认为反映“炎症”或血管损伤的血浆生物标志物。测定 eGFR 和 CMV 抗体（与裂解物、CMV IE-1 或 CMV gB 反应）、ICAM-1、VCAM-1、P-选择素、sIFNαR2、sTNFR1、sCD14 和 CRP 的血浆水平。结论 CMV 抗体水平预测 RTR 而不是健康成人的内皮健康下降，这可能反映了 CMV 的高负担。CMV 抗体水平不能很好地反映被认为反映“炎症”或血管损伤的血浆生物标志物。测定 eGFR 和 CMV 抗体（与裂解物、CMV IE-1 或 CMV gB 反应）、ICAM-1、VCAM-1、P-选择素、sIFNαR2、sTNFR1、sCD14 和 CRP 的血浆水平。结论 CMV 抗体水平预测 RTR 而不是健康成人的内皮健康下降，这可能反映了 CMV 的高负担。CMV 抗体水平不能很好地反映被认为反映“炎症”或血管损伤的血浆生物标志物。