Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.

中文翻译：

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在保护牛结核病的牛中ERAP1和PDE8A被下调。

牛结核病（bTB）是由牛分枝杆菌引起的人畜共患疾病，是全球范围内重大经济损失的原因。尽管具有相关性，但对宿主免疫应答的有效了解有限，长期以来一直阻碍了有效疫苗的开发。鉴定具有与针对bTB的保护相关的表达的宿主蛋白将有助于了解牛对牛分枝杆菌感染的防御机制。在这项研究中，我们发现被保护免于牛分枝杆菌攻击的接种牛中的ERAP1和PDE8A被下调。值得注意的是，两个基因都编码与bTB免疫保护负相关的蛋白质。