This commentary reviews the concept of experience-dependent epigenetic modifications in the CNS as a core mechanism underlying individuality and individuation at the behavioral level. I use the term individuation to refer to the underlying neurobiological processes that result in individuality, with the discussion focusing on individuality of cognitive, emotional, and behavioral repertoire. The review describes recent work supporting the concept of neuroepigenetic mechanisms underlying individuation, possible roles of transgenerational effects, and implications for precision medicine.

中文翻译：

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个体的表观遗传基础。

这篇评论回顾了中枢神经系统中依赖经验的表观遗传修饰的概念，将其作为行为水平下个体化和个体化的核心机制。我使用“个体化”一词来指代导致个体性的潜在神经生物学过程，而讨论的重点是认知，情感和行为方面的个体性。这篇综述描述了支持个性化的神经表观遗传机制概念，转基因作用的可能作用以及对精密医学的启示的最新工作。