Glycans, including glycosphingolipids, are broadly expressed in plasma membranes and play important roles in cell-cell interactions. Recently, it has been revealed that glycans participate in the regulation of malignant phenotypes of cancer cells, e.g. growth and invasion. However, their roles in irradiation-tolerant cancer cells have not yet been elucidated. In this study, we show that specific glycosphingolipids are highly expressed in invasive, irradiation-tolerant lung cancer cells. Particularly, the glycosphingolipid GM2 contributes to the development of an invasive phenotype in these lung cancer cells. Our results suggest that glycosphingolipids, including GM2, are implicated in the regulation of invasiveness in irradiation-tolerant lung cancer cells and may therefore serve as potential therapeutic targets for lung cancers following radiotherapy.Key words: glycosphingolipids, GM2, invasion, lung cancer cells, radiotherapy.

中文翻译：

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糖鞘脂GM2诱导耐辐射肺癌细胞的侵袭。

包括糖鞘脂在内的聚糖在质膜中广泛表达，并在细胞间相互作用中发挥重要作用。最近，已经揭示聚糖参与癌细胞的恶性表型的调节，例如生长和侵袭。然而，尚未阐明它们在耐辐射癌细胞中的作用。在这项研究中，我们表明特定的鞘糖脂在侵袭性，耐辐射的肺癌细胞中高度表达。特别地，糖鞘脂GM2有助于这些肺癌细胞中侵袭性表型的发展。我们的结果表明，糖鞘脂，包括GM2，