Brain function requires precise neural circuit assembly during development. Establishing a functional circuit involves multiple coordinated steps ranging from neural cell fate specification to proper matching between pre- and post-synaptic partners. How neuronal lineage and birth timing influence wiring specificity remains an open question. Recent findings suggest that the relationships between lineage, birth timing, and wiring specificity vary in different neuronal circuits. In this review, we summarize our current understanding of the cellular, molecular, and developmental mechanisms linking neuronal lineage and birth timing to wiring specificity in a few specific systems in Drosophila and mice, and review different methods employed to explore these mechanisms.

中文翻译：

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连接神经元谱系和接线特异性。


大脑功能在发育过程中需要精确的神经回路组装。建立功能回路涉及多个协调步骤，从神经细胞命运规范到突触前和突触后伙伴之间的适当匹配。神经元谱系和出生时间如何影响接线特异性仍然是一个悬而未决的问题。最近的研究结果表明，不同神经元回路中的谱系、出生时间和接线特异性之间的关系有所不同。在这篇综述中，我们总结了我们目前对果蝇和小鼠的一些特定系统中将神经元谱系和出生时间与线路特异性联系起来的细胞、分子和发育机制的理解，并回顾了用于探索这些机制的不同方法。