We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 453 Mexicans from the state of Zacatecas living in Zacatecas city (N = 84), Fresnillo (N = 103) and rural communities (N = 266) to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent haplotypes for the state of Zacatecas include seven Native American most probable ancestry (A*02 ∼ B*39 ∼ DRB1*04 ∼ DQB1*03:02; A*02 ∼ B*35 ∼ DRB1*08 ∼ DQB1*04; A*24 ∼ B*39 ∼ DRB1*14 ∼ DQB1*03:01; A*02 ∼ B*35 ∼ DRB1*04 ∼ DQB1*03:02; A*24 ∼ B*35 ∼ DRB1*04 ∼ DQB1*03:02; A*68 ∼ B*35 ∼ DRB1*04 ∼ DQB1*03:02 and A*24 ∼ B*35 ∼ DRB1*08 ∼ DQB1*04) and two European MPA haplotypes (HLA ∼ A*01 ∼ B*08 ∼ DRB1*03:01 ∼ DQB1*02 and A*29 ∼ B*44 ∼ DRB1*07 ∼ DQB1*02). Admixture estimates revealed that the main genetic components in the state of Zacatecas are European (47.61 ± 1.85%) and Native American (44.74 ± 1.12%), while the African genetic component was less apparent (7.65 ± 1.12%). Our findings provide a starting point for the study of population immunogenetics of urban and rural populations from the state of Zacatecas and add to the growing knowledge on the population genetics of Northern Mexico.

我们研究了HLA I类（HLA-A，-B）和II类（HLA-DRB1，-DQB1）基于PCR-SSP的等位基因在生活在萨卡特卡斯市（N = 84），弗雷斯尼洛（N = 103）和农村社区（N = 266）的萨卡特卡斯州的453名墨西哥人中获得有关等位基因和单倍型频率及其频率的信息连锁不平衡。我们发现萨卡特卡斯州的最常见单倍型包括七个美洲原住民最有血统的祖先（A * 02〜B * 39〜DRB1 * 04〜DQB1 * 03：02; A * 02〜B * 35〜DRB1 * 08〜 DQB1 * 04; A * 24〜B * 39〜DRB1 * 14〜DQB1 * 03：01; A * 02〜B * 35〜DRB1 * 04〜DQB1 * 03：02; A * 24〜B * 35〜DRB1 * 04〜DQB1 * 03：02; A * 68〜B * 35〜DRB1 * 04〜DQB1 * 03：02和A * 24〜B * 35〜DRB1 * 08〜DQB1 * 04）和两种欧洲MPA单倍型（HLA〜 A * 01到B * 08到DRB1 * 03：01到DQB1 * 02和A * 29到B * 44到DRB1 * 07到DQB1 * 02）。混合物估计显示，萨卡特卡斯州的主要遗传成分是欧洲的（47。61±1.85％）和美洲原住民（44.74±1.12％），而非洲遗传成分则不太明显（7.65±1.12％）。我们的发现为研究萨卡特卡斯州的城市和农村人口的群体免疫遗传学提供了起点，并增加了对北墨西哥人口遗传学的认识。