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Exosome-like Nanoparticles: A New Type of Nanocarrier.
Current Medicinal Chemistry ( IF 3.5 ) Pub Date : 2020-06-30 , DOI: 10.2174/0929867326666190129142604
Mário Fernandes 1, 2 , Ivo Lopes 1, 2 , José Teixeira 1 , Cláudia Botelho 1, 2 , Andreia C Gomes 2
Affiliation  

Nanoparticles are one of the most commonly used systems for imaging or therapeutic drug delivery. Exosomes are nanovesicular carriers that transport cargo for intercellular communication. These nanovesicles are linked to the pathology of some major diseases, in some cases with a central role in their progression. The use of these carriers to transport therapeutic drugs is a recent and promising approach to treat diseases such as cancer and Alzheimer disease. The physiological production of these structures is limited impairing its collection and subsequent purification. These drawbacks inspired the search for mimetic alternatives. The collection of exosome-like nanoparticles from plants can be a good alternative, since they are easier to extract and do not have the drawbacks of those produced in animal cells. Both natural and synthetic exosome-like nanoparticles, produced from serial extrusion of cells or by bottom up synthesis, are currently some of the most promising, biocompatible, high efficiency systems for drug delivery.



中文翻译:

类外泌体纳米颗粒:一种新型的纳米载体。

纳米颗粒是用于成像或治疗药物递送的最常用系统之一。外来体是纳米囊载体,其运输货物以进行细胞间通讯。这些纳米囊泡与某些主要疾病的病理学相关,在某些情况下,在其进展中起着核心作用。使用这些载体来运输治疗药物是治疗诸如癌症和阿尔茨海默氏病的疾病的最新且有希望的方法。这些结构的生理产生受到限制,损害了其收集和随后的纯化。这些缺点激发了人们对模仿替代品的追求。从植物中收集外泌体样纳米颗粒可能是一个很好的选择,因为它们更容易提取并且没有动物细胞中产生的缺点。

更新日期:2020-07-01
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