Background: Genetic changes in p53 gene contribute to breast cancer susceptibility. Objective and Methods: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence. Conclusion: The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.

中文翻译：

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p53 arg72pro SNP 对北印度人群乳腺癌风险的影响

背景：p53 基因的遗传变化有助于乳腺癌易感性。目的和方法：进行病例对照研究和荟萃分析，以研究 p53 密码子 72 SNP 与印度女性乳腺癌易感性的作用。结果：在整个队列中，p53 杂合精氨酸变异与乳腺癌风险降低相关。在荟萃分析中，发现等位基因和 GG 与 CC 遗传比较模型与乳腺癌风险相关。此外，隐性比较模型表明与乳腺癌的发生具有保护性相关性。结论：我们的病例对照研究和荟萃分析的结果表明 p53 Arg72Pro 多态性与印度人群乳腺癌风险增加之间存在显着关联。