Muscle homeostasis is guaranteed by a delicate balance between synthesis and degradation of cell proteins and its alteration leads to muscle wasting and diseases. In this review, we describe the major anabolic pathways that are involved in muscle growth and homeostasis and the proteolytic systems that are over-activated in muscle pathologies. Modulation of these pathways comprises an attractive target for drug intervention.

中文翻译：

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对肌肉稳态、萎缩和消耗的分子洞察


细胞蛋白质的合成和降解之间的微妙平衡保证了肌肉稳态，其改变会导致肌肉萎缩和疾病。在这篇综述中，我们描述了参与肌肉生长和稳态的主要合成代谢途径以及在肌肉病理学中过度激活的蛋白水解系统。这些途径的调节构成了药物干预的一个有吸引力的目标。