ABSTRACT We hypothesised that copper nanoparticles (NanoCu), because of their high physicochemical reactivity and bioavailability, could be used in much smaller quantities than bulk Cu, consequently reducing excretion of Cu into the environment. The objective of the study was to evaluate the effects of various levels of NanoCu on the development and growth of broiler chickens, in order to establish an optimum level of NanoCu dietary supplementation. Broiler chickens were randomly divided into five groups of 10 birds each. The control group received 7.5 mg Cu/kg feed (standard level) as CuSO4, while groups fed with complexes of NanoCu and starch received 25%, 50%, 75% and 100% of the standard level of Cu used in the control group. Chicken growth and excretion of Cu, Fe and Zn were measured during the growth period from d 7 to 42. At d 42, the slaughter characteristics, the content of Cu, Fe and Zn in the breast muscle and liver, and the oxidative status were analysed. The results indicate that using NanoCu can reduce the standard level of Cu from CuSO4 supplementation by 75% without jeopardising animal growth, and at the same time significantly decreasing Cu excretion into the environment.

中文翻译：

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纳米铜对鸡组织和粪便矿物质含量及生长的影响

摘要 我们假设铜纳米粒子 (NanoCu) 由于其高物理化学反应性和生物利用度，其用量比大块 Cu 少得多，从而减少了 Cu 排放到环境中。本研究的目的是评估不同水平的 NanoCu 对肉鸡发育和生长的影响，以确定 NanoCu 日粮的最佳添加水平。肉鸡随机分成五组，每组10只。对照组接受 7.5 mg Cu/kg 饲料（标准水平）作为 CuSO4，而喂食纳米铜和淀粉复合物的组接受对照组所用标准水平的 25%、50%、75% 和 100% 的铜。在第 7 天至第 42 天的生长期测量鸡的生长和铜、铁和锌的排泄量。在第 42 天，对屠宰特性、胸肌和肝脏中Cu、Fe、Zn的含量及氧化状态进行了分析。结果表明，使用 NanoCu 可以在不危及动物生长的情况下将 CuSO4 补充中 Cu 的标准水平降低 75%，同时显着减少 Cu 排放到环境中。