The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic pathways and may have therapeutic importance for treating obesity, insulin resistance, type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease (CVD). Given the ubiquitous expression of AMPK, it has been a challenge to evaluate which tissue types may be most beneficially poised for mediating the positive metabolic effects of AMPK-centered treatments. In this review we evaluate the metabolic phenotypes of transgenic mouse models in which AMPK expression and function have been manipulated, and the impact this has on controlling lipid metabolism, glucose homeostasis, and inflammation. This information may be useful for guiding the development of AMPK-targeted therapeutics to treat chronic metabolic diseases.

中文翻译：

---

AMPK 作为治疗代谢疾病的治疗靶点

AMP 活化蛋白激酶 (AMPK) 是多种代谢途径的中心调节剂，可能对治疗肥胖、胰岛素抵抗、2 型糖尿病 (T2D)、非酒精性脂肪肝 (NAFLD) 和心血管疾病具有治疗意义。化学气相沉积）。鉴于 AMPK 的普遍表达，评估哪些组织类型可能最有利于调节以 AMPK 为中心的治疗的积极代谢作用一直是一个挑战。在这篇综述中，我们评估了 AMPK 表达和功能被操纵的转基因小鼠模型的代谢表型，以及这对控制脂质代谢、葡萄糖稳态和炎症的影响。该信息可能有助于指导 AMPK 靶向疗法的开发，以治疗慢性代谢疾病。