This review focuses on recent progress in noncomputational methods to introduce catalytic function into proteins, peptides, and peptide assemblies. We discuss various approaches to creating catalytic activity and classification of noncomputational methods into rational and combinatorial classes. The section on rational design covers recent progress in the development of short peptides and oligomeric peptide assemblies for various natural and unnatural reactions. The section on combinatorial design describes recent advances in the discovery of catalytic peptides. We present the future prospects of these and other new approaches in a broader context, including implications for functional material design.

中文翻译：

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通过合理和组合方法设计催化肽和蛋白质。

本综述重点关注将催化功能引入蛋白质、肽和肽组装体的非计算方法的最新进展。我们讨论了创建催化活性的各种方法以及将非计算方法分类为理性类和组合类。合理设计部分涵盖了用于各种自然和非自然反应的短肽和寡聚肽组装体开发的最新进展。组合设计部分描述了催化肽发现的最新进展。我们在更广泛的背景下展示了这些和其他新方法的未来前景，包括对功能材料设计的影响。