Within this contribution, the development and substrate scope evaluation of a direct alkylation protocol of the C(sp³)–H bond of benzylic amines using alkyl bromides is reported. This pyridine-directed method is initiated by elimination of the alkyl bromide to a terminal olefin, which is then the true alkylating agent.

Graphical abstract

中文翻译：

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铑使​​用烷基溴催化苄胺的直接烷基化。

在这一贡献中，报道了使用烷基溴对苄胺的C（sp ³）-H键进行直接烷基化的研究进展和底物范围的评估。这种吡啶定向方法是通过将烷基溴消除为末端烯烃而引发的，该末端烯烃才是真正的烷基化剂。

图形概要