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Rhodium-catalyzed direct alkylation of benzylic amines using alkyl bromides.
Monatshefte für Chemie - Chemical Monthly ( IF 1.7 ) Pub Date : 2018-11-13 , DOI: 10.1007/s00706-018-2305-9
Martin Anschuber 1 , Robert Pollice 2 , Michael Schnürch 1
Affiliation  

Within this contribution, the development and substrate scope evaluation of a direct alkylation protocol of the C(sp3)–H bond of benzylic amines using alkyl bromides is reported. This pyridine-directed method is initiated by elimination of the alkyl bromide to a terminal olefin, which is then the true alkylating agent.

Graphical abstract



中文翻译:

铑使​​用烷基溴催化苄胺的直接烷基化。

在这一贡献中,报道了使用烷基溴对苄胺的C(sp 3)-H键进行直接烷基化的研究进展和底物范围的评估。这种吡啶定向方法是通过将烷基溴消除为末端烯烃而引发的,该末端烯烃才是真正的烷基化剂。

图形概要

更新日期:2018-11-13
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