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Is C. elegans a suitable model for nutritional science?
Genes and Nutrition ( IF 3.3 ) Pub Date : 2019-01-09 , DOI: 10.1186/s12263-018-0625-3
Dieter-Christian Gottschling 1 , Frank Döring 1
Affiliation  

The suitability of C. elegans as a model for the question of nutritional science is a controversial topic. The discussion makes clear that C. elegans is its own best model for revealing, via genetic approaches, biological principles of nutritional behavior, and the biochemical function of vitamins. In this case, the model has a discovery function. Worm research serves also in the identification of nutrition-dependent pathways that could be used for novel approaches in human nutritional studies. This heuristic function of the model guides the applied nutrition research in an innovative direction. Since the nutrition and metabolism for the worm and man differ from each other somewhat strongly, results of nutritional studies in C. elegans are not directly applicable to human nutrition. In general, the C. elegans model is primarily appropriate for explaining the causality of general species' nutritional phenotypes. Experience tells us that the analysis of drastic nutritional phenotypes in C. elegans has the potential to enrich the canon of knowledge of nutritional science.

中文翻译:

秀丽隐杆线虫是否是营养科学的合适模型?

秀丽隐杆线虫是否适合作为营养科学问题的模型是一个有争议的话题。讨论清楚地表明,秀丽隐杆线虫是其自己的最佳模型,可通过遗传方法,营养行为的生物学原理以及维生素的生化功能来揭示秀丽隐杆线虫。在这种情况下,模型具有发现功能。蠕虫研究还有助于确定依赖营养的途径,这些途径可用于人类营养研究的新方法。该模型的启发式功能将指导营养应用研究朝着创新方向发展。由于蠕虫和人的营养和代谢差异很大,因此秀丽隐杆线虫的营养研究结果并不直接适用于人类营养。一般来说,C 秀丽线虫模型主要适用于解释一般物种营养表型的因果关系。经验告诉我们,对秀丽隐杆线虫激烈的营养表型进行分析具有丰富营养科学知识的潜力。
更新日期:2020-04-22
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