Biological and chemical agents cause dangerous effects on human health via different exposing ways. Recently, herbal medicine is considered as a biological and safe treatment for toxicities. Silybum marianum (milk thistle), belongs to the Asteraceae family, possesses different effects such as hepatoprotective, cardioprotective, neuroprotective, anti-inflammatory and anti-carcinogenic activities. Several studies have demonstrated that this plant has protective properties against toxic agents. Herein, the protective effects of S. marianum and its main component, silymarin, which is the mixture of flavonolignans including silibinin, silydianin and silychristin acts against different biological (mycotoxins, snake venoms, and bacterial toxins) and chemical (metals, fluoride, pesticides, cardiotoxic, neurotoxic, hepatotoxic, and nephrotoxic agents) poisons have been summarized. This review reveals that main protective effects of milk thistle and its components are attributed to radical scavenging, anti-oxidative, chelating, anti-apoptotic properties, and regulating the inflammatory responses.

中文翻译：

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水飞蓟（Silybum Marianum）作为天然或化学毒性的解毒剂或保护剂：综述。


生物制剂和化学制剂通过不同的暴露方式对人体健康造成危险影响。最近，草药被认为是一种生物且安全的毒性治疗方法。水飞蓟（水飞蓟）属于菊科，具有不同的功效，如保肝、心脏保护、神经保护、抗炎和抗癌活性。多项研究表明，这种植物具有针对有毒物质的防护特性。其中，S. marianum 及其主要成分水飞蓟素（水飞蓟素是黄酮木脂素的混合物，包括水飞蓟宾、水飞蓟宁和水飞蓟亭）具有保护作用，可对抗不同的生物（霉菌毒素、蛇毒和细菌毒素）和化学（金属、氟化物、农药） 、心脏毒性、神经毒性、肝毒性和肾毒性药物）毒物已进行了总结。本综述揭示了水飞蓟及其成分的主要保护作用归因于自由基清除、抗氧化、螯合、抗凋亡特性和调节炎症反应。