Copper-nicotinate complex (CNC) has antioxidant activities through scavenging of free radicals formed inside the body. CNC also has anti-tumor and anti-inflammatory activities. The current study was designed to determine the effect of glycerol on rat kidney function and oxidative stress as well as, the potential nephroprotective effects of CNC. Forty male Wistar rats were randomly allocated into four equal groups. The groups of rats were as follows: GI was kept under normal control conditions; GII was orally given CNC at a dose of 0.043 mg kg-1 body weight (BW), three times/week for 4 weeks; GIII was administered glycerol (topical application) at a dose of 3.15 ml kg-1 BW daily for 4 weeks; and GIV was given CNC and glycerol with the same dose and route. The results revealed that CNC improves the renal dysfunctions induced by glycerol by recovering the levels of urea and creatinine to normal, as well as through the antioxidant status manifested by the normalization of catalase, superoxide dismutase, reduced glutathione, and malondialdehyde levels. Moreover, by its effect as an anti-oxidant, CNC reduces the effect of glycerol on the kidney by decreasing the fibrosis, degenerative changes and necrotic changes in the renal tubules. In conclusion, CNC could alleviate the side effects that might be caused by glycerol.

中文翻译：

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烟酸铜配合物对甘油诱导的大鼠肾毒性的保护和抗氧化作用。

烟酸铜络合物（CNC）通过清除体内形成的自由基具有抗氧化活性。CNC还具有抗肿瘤和抗炎活性。当前的研究旨在确定甘油对大鼠肾功能和氧化应激的影响以及CNC的潜在肾保护作用。将四十只雄性Wistar大鼠随机分为四个相等的组。大鼠的分组如下：胃肠道保持在正常对照条件下；GII口服0.043 mg kg-1体重（BW）的剂量的CNC，每周3次，共4周。每天以3.15 ml kg-1 BW的剂量向GIII施用甘油（局部应用），持续4周；给予GIV相同剂量和途径的CNC和甘油。结果表明，CNC通过恢复尿素和肌酐的水平至正常水平，以及通过过氧化氢酶，超氧化物歧化酶，谷胱甘肽和丙二醛水平正常化所表现出的抗氧化状态，来改善甘油引起的肾功能不全。此外，由于其作为抗氧化剂的作用，CNC通过减少肾小管的纤维化，变性变化和坏死变化来降低甘油对肾脏的作用。总之，CNC可以减轻甘油引起的副作用。CNC通过减少肾小管的纤维化，变性变化和坏死变化来降低甘油对肾脏的作用。总之，CNC可以减轻甘油引起的副作用。CNC通过减少肾小管的纤维化，变性变化和坏死变化来降低甘油对肾脏的作用。总之，CNC可以减轻甘油引起的副作用。