Coenurosis, caused by the larval coenurus of the tapeworm Taenia multiceps, is a fatal central nervous system disease in both sheep and humans. Though treatment and prevention options are available, the control of coenurosis still faces presents great challenges. Here, we present a high-quality genome sequence of T. multiceps in which 240 Mb (96%) of the genome has been successfully assembled using Pacbio single-molecule real-time (SMRT) and Hi-C data with a N50 length of 44.8 Mb. In total, 49.5 Mb (20.6%) repeat sequences and 13, 013 gene models were identified. We found that Taenia spp. have an expansion of transposable elements and recent small-scale gene duplications following the divergence of Taenia from Echinococcus, but not in Echinococcus genomes, and the genes underlying environmental adaptability and dosage effect tend to be over-retained in the T. multiceps genome. Moreover, we identified several genes encoding proteins involved in proglottid formation and interactions with the host central nervous system, which may contribute to the adaption of T. multiceps to its parasitic life style. Our study not only provides insights into the biology and evolution of T. multiceps, but also identifies a set of species-specific gene targets for developing novel treatment and control tools for coenurosis.

中文翻译：

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tape虫Ta虫Ta虫的基因组为了解寄生虫机制和控制神经病提供了启示。

由the虫Ta虫（Taenia multiceps）的幼虫enenurus引起的大肠病，在绵羊和人类中都是致命的中枢神经系统疾病。尽管有治疗和预防的选择，但控制神经变性仍面临巨大挑战。在这里，我们介绍了T. multiceps的高质量基因组序列，其中使用Pacbio单分子实时（SMRT）和Hi-C数据成功构建了240 Mb（96％）基因组，其N50长度为44.8 Mb。总共鉴定出49.5 Mb（20.6％）重复序列和13 013个基因模型。我们发现Ta虫属。Ta虫从棘球oc球菌分化后，转座因子的扩增和最近的小规模基因重复，但在棘球oc球菌基因组中没有，并且环境适应性和剂量效应的基因倾向于在多囊隐孢子虫基因组中过度保留。此外，我们确定了几个编码蛋白质的基因，这些蛋白质参与了前突形成和与宿主中枢神经系统的相互作用，这可能有助于多头T虫对其寄生生活方式的适应。我们的研究不仅提供了关于多头T虫生物学和进化的见解，而且还鉴定了一组物种特异性的基因靶标，用于开发新型的治疗方法和控制神经变性的工具。