BACKGROUND In the recent years, polymeric nanofibers have gained lots of attention in the area of drug delivery applications. Owing to its simplicity, ease of composition method and high drug loading capacity, it provides various benefits for the therapeutic applications. Nanofibers are useful for the delivery of antibiotics, anticancer drugs, analgesic's agents and various proteins for drug delivery applications. Electrospinning method is widely used method for the preparation of nanofibers, based on their feasibility background for scale-up process from laboratory to the industrial applications. METHOD A literature review was conducted to summarize the reported articles as well as patents that have been granted and filed for work related to nanofibers in drug delivery. Efforts have been made to include various types of research undertaken by the researchers for the fabrication of nanofiber and its application in drug delivery system. RESULTS In this paper, a detailed information is reported about researches and developments related to electrospun polymer nanofibers including its fabrication process, structure, properties, characterization, applications, and patent. Amongst all the patents available, 18 most relevant granted patents and 14 filed patents was summarized in the review article. CONCLUSION We expect that these fundamental applications of nanofibers could help the researchers to develop and gain knowledge about nanofibers in drug delivery application.

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高分子电纺纳米纤维及其在药物输送中的最新专利。

背景技术近年来，聚合物纳米纤维在药物递送应用领域中引起了很多关注。由于其简单，易于组合的方法和高载药量，它为治疗应用提供了多种益处。纳米纤维可用于递送抗生素，抗癌药，止痛剂和各种蛋白质，以用于药物递送。静电纺丝法是一种广泛用于制备纳米纤维的方法，其基础是从实验室到工业应用的规模放大过程的可行性背景。方法进行了文献综述，总结了报道的文章以及与纳米纤维在药物输送中有关的工作已被授予和申请的专利。已经做出努力以包括研究人员为制造纳米纤维及其在药物递送系统中的应用而进行的各种类型的研究。结果本文报道了有关电纺聚合物纳米纤维研究与开发的详细信息，包括其制造工艺，结构，性能，特性，应用和专利。综述文章总结了所有可用专利中的18项最相关的授权专利和14项提交的专利。结论我们期望纳米纤维的这些基本应用可以帮助研究人员开发和获得有关纳米纤维在药物输送应用中的知识。报告了有关电纺聚合物纳米纤维研究与开发的详细信息，包括其制造工艺，结构，性能，特性，应用和专利。评论文章中总结了所有可用专利中的18个最相关的授权专利和14项提交的专利。结论我们期望纳米纤维的这些基本应用可以帮助研究人员开发和获得有关纳米纤维在药物输送应用中的知识。报告了有关电纺聚合物纳米纤维研究与开发的详细信息，包括其制造工艺，结构，性能，特性，应用和专利。综述文章总结了所有可用专利中的18项最相关的授权专利和14项提交的专利。结论我们期望纳米纤维的这些基本应用可以帮助研究人员开发和获得有关纳米纤维在药物输送应用中的知识。