BACKGROUND Pharmacokinetic issues and poor solubility in water are the most important concerns of numerous recently developed chemical entities. OBJECTIVE The drugs which are poorly soluble in water demonstrate numerous formulating troubles in conventional dosage forms and the low bio-availability is the critical problem linked with it. A nanosponge is an emerging technology which can overcome these problems and precisely control the release rates of controlled drug delivery. METHOD Nanosponges are tiny mesh-like structures with a size less than 1μm. Due to their porous structure and small size; they can easily bind to drugs which are poorly-soluble leading to better bioavailability and solubility of such drugs. A broad range of drugs including both hydrophilic and lipophilic can be easily loaded into nanosponges. RESULTS These minute sponges can circulate until they reach the definite target site, attach themselves to the surface and initiate the discharge of drugs in a predictable and controlled way. Nanosponges are solid in character and can be developed in various dosage forms such as parenteral, topical, oral or inhalational. Nanosponge drug delivery system has been developed as one of the most capable aspects in the field of pharmaceuticals. CONCLUSION In this review, an attempt has been made to highlight the advantages, characteristics, application, methods of preparation and characterization of nanosponges along with the recent patents on nanosponges.

中文翻译：

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Nanosponges-一种有前途的新型药物递送系统。

背景技术药代动力学问题和在水中的不良溶解性是许多最近开发的化学实体最关注的问题。目的难溶于水的药物在常规剂型中显示出许多配制方面的麻烦，而生物利用度低是与此相关的关键问题。纳米海绵是一种新兴技术，可以克服这些问题并精确控制受控药物释放的释放速率。方法纳米海绵是微小的网状结构，尺寸小于1μm。由于其多孔结构和小尺寸；它们可以很容易地与难溶性药物结合，从而获得更好的生物利用度和溶解度。包括亲水性和亲脂性在内的多种药物都可以轻松地装入纳米海绵中。结果这些微小的海绵可以循环直至到达确定的目标部位，将其附着在表面上并以可预测和可控的方式开始释放药物。纳米海绵具有固体特性，可以制成各种剂型，例如肠胃外，局部，口服或吸入剂。Nanosponge药物递送系统已被开发为药物领域中最强大的方面之一。结论在这篇综述中，人们试图突出纳米海绵的优点，特性，应用，制备和表征方法，以及有关纳米海绵的最新专利。纳米海绵具有固体特性，可以制成各种剂型，例如肠胃外，局部，口服或吸入剂。Nanosponge药物递送系统已被开发为药物领域中最强大的方面之一。结论在这篇综述中，人们试图突出纳米海绵的优点，特性，应用，制备和表征方法，以及有关纳米海绵的最新专利。纳米海绵具有固体特性，可以制成各种剂型，例如肠胃外，局部，口服或吸入剂。Nanosponge药物递送系统已被开发为药物领域中最强大的方面之一。结论在这篇综述中，人们试图突出纳米海绵的优点，特性，应用，制备和表征方法，以及有关纳米海绵的最新专利。