Wavefront shaping based on digital optical phase conjugation (DOPC) focuses light through or inside scattering media, but the low speed of DOPC prevents it from being applied to thick, living biological tissue. Although a fast DOPC approach was recently developed, the reported single-shot wavefront measurement method does not work when the goal is to focus light inside, instead of through, highly scattering media. Here, using a ferroelectric liquid crystal based spatial light modulator, we develop a simpler but faster DOPC system that focuses light not only through, but also inside scattering media. By controlling 2.6 × 105 optical degrees of freedom, our system focused light through 3 mm thick moving chicken tissue, with a system latency of 3.0 ms. Using ultrasound-guided DOPC, along with a binary wavefront measurement method, our system focused light inside a scattering medium comprising moving tissue with a latency of 6.0 ms, which is one to two orders of magnitude shorter than those of previous digital wavefront shaping systems. Since the demonstrated speed approaches tissue decorrelation rates, this work is an important step toward in vivo deep-tissue non-invasive optical imaging, manipulation, and therapy.

中文翻译：

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通过毫秒数字光学相位共轭将光聚焦在动态散射介质内。


基于数字光学相位共轭 (DOPC) 的波前整形通过散射介质或在散射介质内部聚焦光线，但 DOPC 的低速度使其无法应用于较厚的活生物组织。尽管最近开发了一种快速 DOPC 方法，但当目标是将光聚焦在内部而不是通过高度散射的介质时，所报告的单次波前测量方法不起作用。在这里，我们使用基于铁电液晶的空间光调制器，开发了一种更简单但更快的 DOPC 系统，该系统不仅可以通过散射介质聚焦光，还可以在散射介质内部聚焦光。通过控制 2.6 × 105 光学自由度，我们的系统将光线聚焦穿过 3 毫米厚的移动鸡组织，系统延迟为 3.0 毫秒。我们的系统使用超声引导的 DOPC 以及二进制波前测量方法，将光聚焦在包含移动组织的散射介质内，延迟时间为 6.0 毫秒，比以前的数字波前整形系统短一到两个数量级。由于所展示的速度接近组织去相关率，这项工作是体内深层组织非侵入性光学成像、操作和治疗的重要一步。