BACKGROUND Green tea extract (GTE) has various health promoting effects on animals and humans. However, the effects of perinatal exposure to GTE on the behavioral aspects of offspring have not been elucidated thus far. GTE was provided for pregnant female mice at concentrations of either 20 or 50 g/L, beginning the day of conception until the third week after delivery, postnatal day 22 (PD 22). Mice pups were subjected to behavioral testing to assess sensory motor reflexes, locomotion, anxiety, and learning on various postnatal days. RESULTS Perinatal exposure to GTE resulted in a significant reduction in body weight, as well as earlier body hair appearance and opening of the eyes. Sensory motor reflexes exhibited faster responses and significant stimulatory effects in pups exposed to GTE. During the adolescent period, male and female offspring exhibited increased locomotor activity (on PD 22), reduced anxiety and fear (on PD 25), and enhanced memory and learning abilities (on PD 30), all in both GTE treated groups. All blood counts (RBCs, WBCs, Hb, and platelets), and glucose, cholesterol, triglyceride, and low density lipoprotein concentrations were significantly lower in the GTE-treated pups; however, there was no effect on high density lipoprotein levels. CONCLUSION Our data provide evidence that the high dose of GTE (50 g/L) had higher anxiolytic properties and positive effects on locomotor activities and sensory motor reflexes, as well as learning and memory of the offspring than the low dose of GTE (20 g/L).

中文翻译：

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胎儿和出生后早期发育过程中暴露于绿茶的小鼠后代的神经行为变化。

背景技术绿茶提取物（GTE）对动物和人类具有多种促进健康的作用。然而，到目前为止，尚未阐明围产期接触GTE对后代行为方面的影响。从怀孕之日至分娩后第三周，即出生后第22天（PD 22），以20或50 g / L的浓度为怀孕的雌性小鼠提供GTE。对幼鼠进行行为测试，以评估其在产后各天的感觉运动反射，运动，焦虑和学习情况。结果围产期暴露于GTE导致体重显着降低，以及较早出现的体毛和眼睛睁开。在暴露于GTE的幼犬中，感觉运动反射表现出较快的响应和明显的刺激作用。在青春期 在两个GTE治疗组中，雄性和雌性后代均表现出运动能力增强（PD 22），焦虑和恐惧减轻（PD 25）以及记忆力和学习能力增强（PD 30）。在GTE处理的幼犬中，所有血细胞计数（RBC，WBC，Hb和血小板）以及葡萄糖，胆固醇，甘油三酸酯和低密度脂蛋白浓度均显着降低。但是，对高​​密度脂蛋白水平没有影响。结论我们的数据提供了证据，表明与低剂量的GTE（20 g）相比，高剂量的GTE（50 g / L）具有更高的抗焦虑特性，对运动活动和感觉运动反射以及后代的学习和记忆具有积极作用。 / L）。在所有接受GTE治疗的组中。在GTE处理的幼犬中，所有血细胞计数（RBC，WBC，Hb和血小板）以及葡萄糖，胆固醇，甘油三酸酯和低密度脂蛋白浓度均显着降低。但是，对高​​密度脂蛋白水平没有影响。结论我们的数据提供了证据，表明与低剂量的GTE（20 g）相比，高剂量的GTE（50 g / L）具有更高的抗焦虑特性并对运动活动和感觉运动反射以及后代的学习和记忆产生积极影响。 / L）。在所有接受GTE治疗的组中。在GTE处理的幼犬中，所有血细胞计数（RBC，WBC，Hb和血小板）以及葡萄糖，胆固醇，甘油三酸酯和低密度脂蛋白浓度均显着降低。但是，对高​​密度脂蛋白水平没有影响。结论我们的数据提供了证据，表明与低剂量的GTE（20 g）相比，高剂量的GTE（50 g / L）具有更高的抗焦虑特性，对运动活动和感觉运动反射以及后代的学习和记忆具有积极作用。 / L）。