BACKGROUND Fractalkine (FKN) is an inflammatory cytokine that has been shown with increased serum levels in diabetic patients and is considered to contribute to the adipose tissue inflammation by supporting monocyte adhesion to adipocytes which has an important role in the pathogenesis of type 2 diabetes mellitus (T2DM). Our aim was to evaluate the effects of glucose ingestion on the serum fractal - kine levels in healthy subjects with normal glucose tolerance (NGT) and newly diagnosed T2DM patients. METHODS A total of 67 patients were included in this study, and they were divided into NGT (n=34) and T2DM (n=33) groups according to their oral glucose tolerance test (OGTT) results. The serum FKN and C-reactive protein (CRP) levels were measured at 0 and 120 minutes during an OGTT following overnight fasting. RESULTS The 0-minute (basal) and 120-minute OGTT FKN levels were found to be significantly higher in the T2DM group when compared to the NGT group (p=0.012 and p=0.001, respectively). However, no significant differences were observed in terms of the changes in the basal and 120-minute OGTT FKN levels in the T2DM and NGT groups (p=0.433 and p=0.06, respectively). A significant positive correlation was observed between the 120-minute OGTT FKN and glucose levels in the study group consisting of all of the patients (r=0.331, p=0.006). CONCLUSIONS In this study, basal and post-glycemic load FKN levels were found to be higher in newly diagnosed T2DM patients than those with NGT; however, there was no additional change in FKN levels by glycemic load.

中文翻译：

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葡萄糖摄入对健康受试者和新诊断 2 型糖尿病患者血清 Fractalkine 水平的影响。

背景 Fractalkine (FKN) 是一种炎症细胞因子，在糖尿病患者中显示其血清水平升高，并被认为通过支持单核细胞与脂肪细胞的粘附而导致脂肪组织炎症，这在 2 型糖尿病的发病机制中具有重要作用。 T2DM）。我们的目的是评估葡萄糖摄入对糖耐量正常 (NGT) 的健康受试者和新诊断的 T2DM 患者血清分形因子水平的影响。方法本研究共纳入67例患者，根据口服葡萄糖耐量试验（OGTT）结果分为NGT组（n=34）和T2DM组（n=33）。在禁食过夜后 OGTT 期间的 0 和 120 分钟测量血清 FKN 和 C 反应蛋白 (CRP) 水平。结果发现 T2DM 组的 0 分钟（基础）和 120 分钟 OGTT FKN 水平显着高于 NGT 组（分别为 p=0.012 和 p=0.001）。然而，T2DM 组和 NGT 组的基础和 120 分钟 OGTT FKN 水平的变化没有观察到显着差异（分别为 p=0.433 和 p=0.06）。在所有患者组成的研究组中，120 分钟 OGTT FKN 与血糖水平之间观察到显着正相关（r=0.331，p=0.006）。结论 在这项研究中，发现新诊断的 T2DM 患者的基础和血糖负荷后 FKN 水平高于 NGT 患者；然而，血糖负荷并没有导致 FKN 水平发生额外变化。