BACKGROUND The aim of this study was to investigate the influence of IL-6, TNF-α and hs-CRP on insulin sensitivity during postoperative follow-up in patients with laparoscopic cholecystectomy (LC) or open hernia repair (OHR). METHODS 65 patients were studied: after laparoscopic cholecystectomy (LC; n=40) or open hernia repair (OHR; n=25). Glucose, insulin, hs-CRP, IL-6 and TNF-a were determined at day 0 (before the operation) and at days 1, 3 and 7 (after the operation). RESULTS There were no difference between LC and OHR groups concerning age, BMI, glucose, insulin, hs-CRP, IL-6 and TNF-α at day 0. hs-CRP increased at day 1, 3 and 7 vs. day 0 (p<0.0005), without difference between groups (p=0.561). IL-6 increased at day 1 and day 3 vs. day 0 (p<0.005). IL-6 was higher at day 1 in OHR group in comparison with LC group (p=0.044). There were no differences in TNF-a levels between LC and OHR groups (p=0.056). There was increase of HOMA-IR at day 1, 3 and 7 vs. day 0 (p<0.0005) in both groups. Significantly higher increase of HOMA-IR was in OHR group compared with LC group at day 1 (p=0.045). There was a positive correlation between hs-CRP and HOMA-IR (r=0.46; p=0.025) and between IL-6 and HOMA-IR at day 1 in OHR group (r=0.44; p=0.030). CONCLUSIONS Significantly higher HOMA-IR was found in OHR group compared with LC. Positive correlation between hs-CRP and IL-6 with HOMA-IR in OHR group at day 1, indicate possible influence of this mediators on impairment of insulin sensitivity.

中文翻译：

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IL-6、TNF-α和Hs-CRP对腹腔镜胆囊切除术或开腹疝修补术后患者胰岛素敏感性的影响。


背景本研究的目的是探讨腹腔镜胆囊切除术（LC）或开腹疝修补术（OHR）患者术后随访期间IL-6、TNF-α和hs-CRP对胰岛素敏感性的影响。方法 对 65 名患者进行了研究：腹腔镜胆囊切除术 (LC；n=40) 或开放式疝修补术 (OHR；n=25)。在第0天（手术前）和第1、3和7天（手术后）测定血糖、胰岛素、hs-CRP、IL-6和TNF-a。结果 LC组和OHR组在第0天的年龄、BMI、血糖、胰岛素、hs-CRP、IL-6和TNF-α方面没有差异。与第0天相比，hs-CRP在第1、3和7天增加（ p<0.0005)，组间无差异 (p=0.561)。与第 0 天相比，IL-6 在第 1 天和第 3 天增加 (p<0.005)。与 LC 组相比，OHR 组第 1 天的 IL-6 较高（p=0.044）。 LC 组和 OHR 组之间的 TNF-a 水平没有差异 (p=0.056)。与第 0 天相比，两组的 HOMA-IR 在第 1、3 和 7 天都有增加 (p<0.0005)。第 1 天时，OHR 组的 HOMA-IR 增幅显着高于 LC 组（p=0.045）。 OHR 组第 1 天时 hs-CRP 与 HOMA-IR 呈正相关（r=0.46；p=0.025），IL-6 与 HOMA-IR 呈正相关（r=0.44；p=0.030）。结论 与 LC 相比，OHR 组的 HOMA-IR 显着升高。 OHR 组第 1 天 hs-CRP 和 IL-6 与 HOMA-IR 之间呈正相关，表明该介质可能对胰岛素敏感性受损产生影响。