Chemogenetic technologies enable selective pharmacological control of specific cell populations. An increasing number of approaches have been developed that modulate different signaling pathways. Selective pharmacological control over G protein-coupled receptor signaling, ion channel conductances, protein association, protein stability, and small molecule targeting allows modulation of cellular processes in distinct cell types. Here, we review these chemogenetic technologies and instances of their applications in complex tissues in vivo and ex vivo.

中文翻译：

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因果细胞和神经元生物学的化学生成工具。

化学发生技术能够选择性地控制特定细胞群的药理作用。已经开发出越来越多的方法来调节不同的信号传导途径。对G蛋白偶联受体信号传导，离子通道电导，蛋白缔合，蛋白稳定性和小分子靶向的选择性药理控制，可以调节不同细胞类型中的细胞过程。在这里，我们回顾了这些化学发生技术及其在体内和离体的复杂组织中的应用实例。