Introduction

Chemesthetic compounds, responsible for sensations such as burning, cooling, and astringency, are difficult stimuli to work with, especially when the evaluation task requires retasting.

Methods

Here, we developed a protocol by which chemesthetic compounds can be assessed using sorting. We compared the performance of two cohorts of untrained assessors on this task, one with nose clips and the other without. Similarity matrices were analyzed using multidimensional scaling (MDS) to produce perceptual maps for the two cohorts

Results

Overall, the groupings from the nose-open cohort tended to follow a biological basis, consistent with previous findings that suggest compounds that activate a common receptor will elicit similar sensations. The nose-open and nose-pinched cohorts generated significantly different maps. The nose-pinched cohort had a higher variance in the MDS solution than the nose-open group. While the nose-open cohort generated seven clusters, the nose-pinched cohort generated only two clusters, seemingly based on the ready identification of chemesthetic sensations or not. There was less consensus regarding the attributes used to describe the samples in the nose-pinched cohort than in the nose-open cohort as well, as this cohort collectively generated more attributes but fewer were significant in regression.

Conclusion

Sorting can be used with orally delivered chemesthetic stimuli in naive assessors, and the resulting perceptual maps differ when nose clips are worn.

中文翻译：

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幼稚评估者对化学刺激的感知映射。

 介绍

化学感觉化合物负责产生灼烧感、清凉感和涩味等感觉，是很难处理的刺激物，特别是当评估任务需要重新品尝时。

 方法

在这里，我们开发了一个协议，通过该协议可以使用排序来评估化学感觉化合物。我们比较了两组未经训练的评估员在这项任务中的表现，一组有鼻夹，另一组没有。使用多维尺度（MDS）分析相似性矩阵，为两个队列生成感知图

 结果

总体而言，开放鼻子队列的分组倾向于遵循生物学基础，这与之前的研究结果一致，即激活共同受体的化合物会引起类似的感觉。张鼻子和捏鼻子的两组人生成的地图明显不同。捏鼻子组的 MDS 解决方案的方差高于张鼻组。张鼻子组产生了七个簇，而捏鼻子组只产生了两个簇，这似乎是基于是否已经对化学感觉进行了现成的识别。关于用于描述捏鼻子队列中样本的属性，与打开鼻子队列中的样本属性相比，共识较少，因为该队列共同生成了更多属性，但在回归中显着的属性较少。

 结论

分类可以与天真的评估者口服化学刺激一起使用，并且当佩戴鼻夹时，所得的感知图会有所不同。