In the space of little more than a decade, ideas of the human genome have shifted significantly, with the emergence of the notion that the genome of an individual changes with development, age, disease, environmental inputs, and time. This paper examines the emergence of the genome with a life span, one that experiences drift, instability, and mutability, and a host of other temporal changes. We argue that developments in chromatin biology have provided the basis for this genomic embodiment of experience and exposure. We analyze how time has come to matter for the genome through chromatin, providing analysis of examples in which the human life course is being explored as a set of material changes to chromatin. A genome with a life span aligns the molecular and the experiential in new ways, shifting ideas of life stages, their interrelation, and the temporality of health and disease.

中文翻译：

---

基因组如何获得寿命


在不到十年的时间里，人类基因组的观念发生了重大转变，出现了个体基因组随着发育、年龄、疾病、环境输入和时间而变化的观念。本文研究了具有生命周期的基因组的出现，该基因组经历了漂移、不稳定性和可变性，以及一系列其他时间变化。我们认为，染色质生物学的发展为这种经验和暴露的基因组体现提供了基础。我们分析了时间如何通过染色质对基因组产生影响，并提供了一些示例分析，其中人类生命历程被探索为染色质的一系列物质变化。具有寿命的基因组以新的方式将分子和经验结合起来，改变了对生命阶段、它们之间的相互关系以及健康和疾病的暂时性的看法。