Curcumin feeding of Drosophila larvae or young adults inhibits TOR and other known longevity genes and induces an extended health span in a normal-lived Ra strain adult. Combining larval curcumin feeding with an adult dietary restriction (DR) diet does not yield an additive effect. The age-specific mortality rate is decreased and is comparable with that of genetically selected long-lived La animals. Feeding Ra adults with the drug their whole life, or only during the senescent span, results in a weak negative effect on median longevity with no increase in maximum lifespan. The La strain shows no response to this DR mimetic. Thus, curcumin acts in a life stage-specific manner to extend the health span. Histone deacetylase inhibitors decrease the longevity of Ra animals if administered over the health span only or over the entire adult lifespan, but these inhibitors increase longevity when administered in the transition or senescent spans. Their major effect is a reduction in the mortality rate of older flies, raising the possibility of reducing frailty in older organisms. Their life stage-specific effects are complementary to that of curcumin. Use of stage-specific drugs may enable targeted increases in health or senescent spans, and thus selectively increase the quality of life.

中文翻译：

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果蝇健康和衰老跨度的独立化学调节

果蝇幼虫或年轻成虫的姜黄素喂养抑制 TOR 和其他已知的长寿基因，并在正常生活的 Ra 菌株成虫中诱导延长健康跨度。将幼虫姜黄素喂养与成人饮食限制 (DR) 饮食相结合不会产生累加效应。年龄特异性死亡率降低，与基因选择的长寿 La 动物的死亡率相当。终生或仅在衰老期间用药物喂养 Ra 成年人，会对中位寿命产生微弱的负面影响，但不会增加最大寿命。La 菌株对这种 DR 模拟物没有反应。因此，姜黄素以特定于生命阶段的方式起作用以延长健康跨度。组蛋白去乙酰化酶抑制剂如果仅在健康期或整个成年期给药，则会降低 Ra 动物的寿命，但这些抑制剂在过渡期或衰老期给药时会延长寿命。它们的主要作用是降低老年苍蝇的死亡率，增加减少老年生物体虚弱的可能性。它们的生命阶段特定效应与姜黄素的效应相辅相成。使用特定阶段的药物可以有针对性地延长健康或衰老跨度，从而有选择地提高生活质量。