Mass spectrometry (MS) is one of the key analytical technology on which the emerging ‘‘-omics’’ approaches are based. It may provide detection and quantization of thousands of proteins and biologically active metabolites from a tissue, body fluid or cell culture working in a ‘‘global’’ or ‘‘targeted’’ manner, down to ultra-trace levels. It can be expected that the high performance of MS technology, coupled to routine data handling, will soon bring fruit in the request for a better understanding of human diseases, leading to new molecular biomarkers, hence affecting drug targets and therapies. In this review, we focus on the main advances in the MS technologies, influencing genomics, transcriptomics, proteomics, lipidomics and metabolomics fields, up to the most recent MS applications to meta-omic studies.

中文翻译：

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质谱在“组学”时代的作用

质谱 (MS) 是新兴的“组学”方法所基于的关键分析技术之一。它可以检测和量化来自组织、体液或细胞培养物的数千种蛋白质和生物活性代谢物，以“全局”或“靶向”方式工作，直至超痕量水平。可以预期，MS 技术的高性能与常规数据处理相结合，将很快为更好地了解人类疾病的要求带来成果，从而产生新的分子生物标志物，从而影响药物靶点和治疗方法。在这篇综述中，我们关注 MS 技术的主要进展，影响基因组学、转录组学、蛋白质组学、脂质组学和代谢组学领域，直到最近 MS 在元组学研究中的应用。