Misfolding of a protein is a destructive process for variety of diseases that include neurodegenerative diseases such as Alzheimer's disease, Parkinson disease, Huntington disease, mad cow disease, amyotrophic lateral sclerosis (ALS), and frontal temporal dementia (FTD), and other non-CNS diseases such as diabetes, cystic fibrosis, and lysosomal storage diseases. Formation of various misfunctional large assembles of the misfolded protein is the primary consequence. To detect the formation of the aggregated species is very important for not only basic mechanism research but also very crucial for diagnosis of the diseases. In this review, we updated references related to the new development of the dual functional fluorescent small molecule probes for detecting the aggregated proteins in vitro and in vivo.

中文翻译：

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双功能小分子探针作为错误折叠蛋白质的荧光团和配体

蛋白质的错误折叠是多种疾病的破坏性过程，包括神经退行性疾病，如阿尔茨海默病、帕金森病、亨廷顿病、疯牛病、肌萎缩侧索硬化 (ALS) 和额颞叶痴呆 (FTD)，以及其他非中枢神经系统疾病，如糖尿病、囊性纤维化和溶酶体贮积病。主要结果是形成错误折叠蛋白质的各种错误功能大组装。检测聚集物种的形成不仅对于基础机制研究非常重要，而且对于疾病的诊断也非常关键。在这篇综述中，我们更新了与用于检测体外和体内聚集蛋白的双功能荧光小分子探针的新开发相关的参考文献。