Supramolecular chemists continuously take inspiration from complex biological systems to develop functional molecules involved in molecular recognition and self-assembly. In this regard, ‘smart’ synthetic molecules that emulate allosteric proteins are both exciting and challenging, because many allosteric proteins can be considered as molecular switches that bind to other protein targets in a non-covalent fashion and, importantly, are capable of having their output activity controlled by prior binding to input molecules. This review discusses the foundations and passage towards the development of non-covalently operated oligonucleotide-based systems with protein-binding capacity that can be precisely regulated in an input-controlled manner.

中文翻译：

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用于输入控制和非共价调节蛋白质结合的基于寡核苷酸的系统

超分子化学家不断从复杂的生物系统中汲取灵感，以开发参与分子识别和自组装的功能分子。在这方面，模拟变构蛋白的“智能”合成分子既令人兴奋又具有挑战性，因为许多变构蛋白可以被视为以非共价方式与其他蛋白质靶标结合的分子开关，并且重要的是，能够将它们的输出活性由先前与输入分子的结合控制。本综述讨论了开发非共价操作的基于寡核苷酸的系统的基础和途径，该系统具有可以以输入控制方式精确调节的蛋白质结合能力。