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Antioxidant activity of polyphenols from seeds of Vitis amurensis in vitro.
Acta Pharmacologica Sinica ( IF 4.010 ) Pub Date : 2001-05-22
J N Wang,Y J Chen,Y Hano,T Nomura,R X Tan

AIM To study the antioxidant action of five polyphenols (+) catechin, procyanidin B2, procyanidin B5, procyanidin B5 3'-O-gallate, and amurensisin isolated from the seeds of Vitis amurensis. METHODS The mouse liver homogenate lipid peroxidation assay was applied for the evaluation of the antioxidant activity in vitro. RESULTS (+) Catechin, procyanidin B2, procyanidin B5, procyanidin B5 3'-O-gallate, and amurensisin showed antioxidant activity with the IC50 values of 0.47, 0.25, 0.10, 0.02, and 0.03 mmol/L, respectively. The IC50 value of vitamin E used as a positive control was 0.13 mmol/L. The structural activity relationship was also analyzed. Procyanidins carrying a galloyl group possessed higher anti-lipid peroxidation activities. All dimers were found to be more potent than the non-galloylated momomer such as (+) catechin. However, the activity of the 4-->6 linked dimer seemed more preferable than 4-->8 linked dimer. CONCLUSION Procyanidin B5, procyanidin B5 3'-O-gallate, and amurensisin showed a more antioxidant activity than vitamin E did, and their activity is dependent on their substitution and polymerization patterns.
更新日期:2019-11-01

 

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