Cigarette smoking presents oral health professionals with a clinical and research conundrum: reduced periodontal vascular responsiveness to the oral biofilm accompanied by increased susceptibility to destructive periodontal diseases. This presents a significant problem, hampering diagnosis and complicating treatment planning. The aim of this review is to summarize contemporary hypotheses that help to explain mechanistically the phenomenon of a suppressed bleeding response to dysbiotic plaque in the periodontia of smokers. The influence of smoke exposure on angiogenesis, innate cell function, the production of inflammatory mediators including cytokines and proteases, tobacco‐bacteria interactions, and potential genetic predisposition are discussed.

中文翻译：

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烟草引起的血管对牙菌斑反应的抑制。


吸烟给口腔健康专业人员带来了临床和研究难题：牙周血管对口腔生物膜的反应性降低，同时对破坏性牙周疾病的易感性增加。这提出了一个重大问题，阻碍了诊断并使治疗计划复杂化。本综述的目的是总结当代的假设，这些假设有助于从机制上解释吸烟者牙周病菌斑对出血反应的抑制现象。讨论了烟雾暴露对血管生成、先天细胞功能、炎症介质（包括细胞因子和蛋白酶）的产生、烟草-细菌相互作用以及潜在遗传倾向的影响。