This review highlights the design principles, progress and advantages attributed to the structural diversity associated with both natural and synthetic multivalent antimicrobial peptides (AMPs). Natural homo- or hetero-dimers of AMPs linked by intermolecular disulfide bonds existed in the animal kingdom, but the multivalency strategy has been adopted to create synthetic branched or polymeric AMPs that do not exist in nature. The multivalent strategy for the design of multivalent AMPs provides advantages to overcome the challenges faced in clinical applications of AMPs, such as: stability, efficiency, toxicity, maintenance of activity in high salt concentrations and under physiological conditions, and importantly overcoming bacterial resistance which is currently a leading health problem in the world. The multivalency strategy is valuable for moving multivalent AMPs toward clinical applications.

中文翻译：

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多价抗菌肽作为治疗剂：设计原则和结构多样性。

本综述重点介绍了与天然和合成多价抗菌肽 (AMP) 相关的结构多样性的设计原则、进展和优势。通过分子间二硫键连接的 AMP 的天然同二聚体或异源二聚体存在于动物王国中，但已采用多价策略来创建自然界中不存在的合成支链或聚合 AMP。用于设计多价 AMP 的多价策略提供了克服 AMP 临床应用中面临的挑战的优势，例如：稳定性、效率、毒性、在高盐浓度和生理条件下保持活性，以及​​重要的是克服细菌耐药性，这是目前是世界上主要的健康问题。