Therapeutic treatments based on the injection of living cells are in clinical use and preclinical development for diseases ranging from cancer to cardiovascular disease to diabetes. To enhance the function of therapeutic cells, a variety of chemical and materials science strategies are being developed that engineer the surface of therapeutic cells with new molecules, artificial receptors, and multifunctional nanomaterials, synthetically endowing donor cells with new properties and functions. These approaches offer a powerful complement to traditional genetic engineering strategies for enhancing the function of living cells.

中文翻译：

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从外到内增强细胞疗法：使用合成纳米材料的细胞表面工程


基于活细胞注射的治疗方法已应用于癌症、心血管疾病和糖尿病等多种疾病的临床使用和临床前开发中。为了增强治疗细胞的功能，人们正在开发各种化学和材料科学策略，用新分子、人工受体和多功能纳米材料改造治疗细胞的表面，综合赋予供体细胞新的特性和功能。这些方法为增强活细胞功能的传统基因工程策略提供了强有力的补充。