We present a rigorous procedure to derive coarse-grained red blood cell (RBC) models, which yield accurate mechanical response. Based on a semi-analytic theory the linear and nonlinear elastic properties of healthy and infected RBCs in malaria can be matched with those obtained in optical tweezers stretching experiments. The present analysis predicts correctly the membrane Young's modulus in contrast to about 50% error in predictions by previous models. In addition, we develop a stress-free model which avoids a number of pitfalls of existing RBC models, such as non-smooth or poorly controlled equilibrium shape and dependence of the mechanical properties on the initial triangulation quality. Here we employ dissipative particle dynamics for the implementation but the proposed model is general and suitable for use in many existing continuum and particle-based numerical methods.

中文翻译：

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血影蛋白水平红细胞模型的系统粗粒度化

我们提出了一个严格的程序来推导粗粒红细胞 (RBC) 模型，从而产生准确的机械响应。基于半解析理论，疟疾中健康和感染红细胞的线性和非线性弹性特性可以与在光镊拉伸实验中获得的特性相匹配。本分析正确预测了膜杨氏模量，而先前模型的预测误差约为 50%。此外，我们开发了一种无应力模型，它避免了现有 RBC 模型的许多缺陷，例如不光滑或控制不佳的平衡形状以及机械性能对初始三角测量质量的依赖性。